Emblica officinalis (amla) improves lipid metabolism by modulating hepatic forkhead transcription factor box O1 (FoxO1)
نویسندگان
چکیده
منابع مشابه
Phytochemical and Toxicity Study of Emblica Officinalis (amla)
In the present study, phytochemistry and toxicities (acute and chronic) of Emblica officinalis fruit (Amla) have been determined. The hydroalcoholic extract (HAE) of amla was prepared and its extractability was found to be 46.9%. Different chemical tests showed the presence of various active principles or phytoconstituents, viz., alkaloids, glycosides, reducing sugars, tannins, resins, saponins...
متن کاملAntioxidant activity of active tannoid principles of Emblica officinalis (amla).
The antioxidant activity of tannoid active principles of E. officinalis consisting of emblicanin A (37%), emblicanin B (33%), punigluconin (12%) and pedunculagin (14%), was investigated on the basis of their effects on rat brain frontal cortical and striatal concentrations of the oxidative free radical scavenging enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GP...
متن کاملInfluence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats.
The effects of amla on low-density lipoprotein (LDL) oxidation and cholesterol levels were investigated in vitro and in vivo using Cu(2+)-induced LDL oxidation and cholesterol-fed rats. SunAmla and ethyl acetate (EtOAc) extract of amla significantly inhibited thiobarbituric acid (TBA)-reactive substance level in the Cu(2+)-induced LDL oxidation and the effects were stronger than those of probuc...
متن کاملDual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism.
Hepatic insulin resistance affects both carbohydrate and lipid metabolism. It has been proposed that insulin controls these 2 metabolic branches through distinct signaling pathways. FoxO transcription factors are considered effectors of the pathway regulating hepatic glucose production. Here we show that adenoviral delivery of constitutively nuclear forkhead box O1 (FoxO1) to mouse liver result...
متن کاملCorrelation of forkhead box transcription factor O1 and myosin heavy chain isoforms in porcine skeletal muscle.
We examined the expression of myosin heavy chain (MyHC) isoforms and forkhead box transcription factor O1 (FoxO1) in porcine soleus and extensor digitorum longus (EDL) muscles to clarify the correlation of FoxO1 and the relative abundance of transcripts of MyHC isoforms. Soleus muscle was found to be redder than EDL muscles in pigs, and immunohistochemical fast MyHC staining showed more oxidati...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2011
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.25.1_supplement.764.1